Prevalence and Factors Associated with Hydatidiform Mole among Patients with Missed Abortion

Authors

  • Dr. Trifa Yousif Mutalib Author

DOI:

https://doi.org/10.22161/

Abstract

A large number of studies have reported different prevalence rates for hydatidiform mole in different regions, making it difficult to determine the exact prevalence of this condition. There has been no previous study that has determined the prevalence of HM and the risk factors associated with it among patients who have had an missed abortion and were evacuated from the Medical Center and private hospitals in Erbil. Between August 2015 and October 2021, a total of 180 patients who had undergone amissed abortion were enrolled.. Participation in this study was voluntary and included one hundred and eighty  patients with missed abortions who were scheduled for uterine evacuation. The prevalence of HM was 12.8 percent in the overall population. The vast majority of patients with HM (27.5 percent) were under the age of twenty-one years. Risk factors such as parity, contraceptive use, previous abortion, and blood group were not found to have a statistically significant association with the outcome. Prevalence of HM among patients with missed abortion was high (12.8 percent), with age between 15-20 years being the only significant risk factor associated with the presence of HM among those who had anmissed abortion. As a result, we recommend that evacuated products of conception be submitted for histopathological analysis in order to reduce the number of missed opportunities.

Downloads

Download data is not yet available.

References

Aguinaga, M., Rezaei, M., Monroy, I., Mechtouf, N., Pérez, J., Moreno, E., ... & Slim, R. (2021). The genetics of recurrent hydatidiform moles in Mexico: further evidence of a strong founder effect for one mutation in NLRP7 and its widespread. Journal of Assisted Reproduction and Genetics, 1-8.

Aiob, A., Naskovica, K., Sharon, A., & Bornstein, J. (2021). A possible association between hydatidiform mole and the COVID-19 pandemic: A retrospective cohort study. Gynecologic Oncology, 161(2), 454-457.

Anguiano, A., Wang, B. T., Lammers, K. Y., Mahon, L. W., Truitt, N., Dohany, L., & Boyar, F. Z. (2020). Single Nucleotide Polymorphism-Based Chromosomal Microarray Evaluation of Hydatidiform Moles: A US National Reference Laboratory Experience. Open Journal of Obstetrics and Gynecology, 10(8), 1122-1134.

Buza, N., McGregor, S. M., Barroilhet, L., Zheng, X., & Hui, P. (2019). Paternal uniparental isodisomy of tyrosine hydroxylase locus at chromosome 11p15. 4: spectrum of phenotypical presentations simulating hydatidiform moles. Modern Pathology, 32(8), 1180-1188.

Cozette, C., Scheffler, F., Lombart, M., Massardier, J., Bolze, P. A., Hajri, T., ... & Cabry, R. (2020). Pregnancy after oocyte donation in a patient with NLRP7 gene mutations and recurrent molar hydatidiform pregnancies. Journal of Assisted Reproduction and Genetics, 37(9), 2273-2277.

Fallahi, J., Razban, V., Momtahan, M., Akbarzadeh-Jahromi, M., Namavar-Jahromi, B., Anvar, Z., & Fardaei, M. (2019). A novel mutation in NLRP7 related to recurrent hydatidiform mole and reproductive failure. International journal of fertility & sterility, 13(2), 135.

Hemida, R., van Doorn, H., & Fisher, R. (2020). A Novel Genetic Mutation in an Egyptian Patient with Recurrent Biparental Complete Hydatidiform Mole. Studies on Gestational Trophoblastic Disease, with Emphasis on Improving Care in Egypt, and Second Curettage in Low Risk Gestational Trophoblastic Neoplasia., 26, 98.

Jauniaux, E., Memtsa, M., Johns, J., Ross, J. A., Sebire, N. J., & Jurkovic, D. (2020). Ultrasound diagnosis of complete and partial hydatidiform moles in early pregnancy failure: An inter-observer study. Placenta, 97, 65-67.

Ji, M., Shi, X., Xiang, Y., Cui, Q., & Zhao, J. (2019). NLRP7 and KHDC3L variants in Chinese patients with recurrent hydatidiform moles. Japanese journal of clinical oncology, 49(7), 620-627.

Khawajkie, Y., Mechtouf, N., Nguyen, N. M. P., Rahimi, K., Breguet, M., Arseneau, J., ... & Slim, R. (2020). Comprehensive analysis of 204 sporadic hydatidiform moles: revisiting risk factors and their correlations with the molar genotypes. Modern Pathology, 33(5), 880-892.

Khooei, A., Pasdar, F. A., Fazel, A., Mahmoudi, M., Nikravesh, M. R., & Shahbazian, S. D. (2019). Expression of Pro-Apoptotic Bax and Anti-Apoptotic Bcl-2 Proteins in Hydatidiform Moles and Placentas With Hydropic Changes. Acta Medica Iranica, 27-32.

Lama, P., & Pariyar, J. (2021). Histological analysis of the products of conception in first trimester spontaneous abortions. Nepal Journal of Obstetrics and Gynaecology, 16(1).

Li, M. W., Li, F., Cheng, J., Wang, F., & Zhou, P. (2021). Recurrent Androgenetic Complete Hydatidiform Moles with p57KIP2-Positive in a Chinese Family. Reproductive Sciences, 1-7.

Li, P. C., Chang, K. H., & Ding, D. C. (2021). Incomplete abortion with elevated beta-human chorionic gonadotropin levels mimicking a molar pregnancy: A case report. Medicine: Case Reports and Study Protocols, 2(9), e0134.

Löb, S., Vattai, A., Kuhn, C., Schmoeckel, E., Mahner, S., Wöckel, A., ... & Vilsmaier, T. (2020). Spliceosome protein EFTUD2 is upregulated in the trophoblast of spontaneous miscarriage and hydatidiform mole. Journal of Reproductive Immunology, 140, 103149.

Lund, H., Vyberg, M., Eriksen, H. H., Grove, A., Jensen, A. Ø., & Sunde, L. (2020). Decreasing incidence of registered hydatidiform moles in Denmark 1999–2014. Scientific reports, 10(1), 1-10.

Memtsa, M., Johns, J., Jurkovic, D., Ross, J. A., Sebire, N. J., & Jauniaux, E. (2020). Diagnosis and outcome of hydatidiform moles in missed-miscarriage: a cohort-study, systematic review and meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 253, 206-212.

Moein-Vaziri, N., Fallahi, J., Namavar-Jahromi, B., Fardaei, M., Momtahan, M., & Anvar, Z. (2018). Clinical and genetic-epigenetic aspects of recurrent hydatidiform mole: a review of literature. Taiwanese Journal of Obstetrics and Gynecology, 57(1), 1-6.

Mulisya, O., Roberts, D. J., Sengupta, E. S., Agaba, E., Laffita, D., Tobias, T., ... & Mugisha, J. (2018). Prevalence and factors associated with hydatidiform mole among patients undergoing uterine evacuation at mbarara regional referral hospital. Obstetrics and gynecology international, 2018.

Nguyen, N. M. P., Ge, Z. J., Reddy, R., Fahiminiya, S., Sauthier, P., Bagga, R., ... & Slim, R. (2018). Causative mutations and mechanism of androgenetic hydatidiform moles. The American Journal of Human Genetics, 103(5), 740-751.

Nguyen, N. M. P., Khawajkie, Y., Mechtouf, N., Rezaei, M., Breguet, M., Kurvinen, E., ... & Slim, R. (2018). The genetics of recurrent hydatidiform moles: new insights and lessons from a comprehensive analysis of 113 patients. Modern Pathology, 31(7), 1116-1130.

Patil, B. U., Gangane, N. M., & Shivkumar, V. B. (2020). The frequency of hydatidiform mole in a tertiary care hospital from central India. Indian Journal of Pathology and Oncology, 7(1), 71-75.

Ronnett, B. M. (2019). Hydatidiform moles: differential diagnosis, diagnostic reproducibility, genetics and ancillary techniques to refine diagnosis. Diagnostic Histopathology, 25(2), 35-52.

Sato, A., Usui, H., & Shozu, M. (2019). Comparison between vacuum aspiration and forceps plus blunt curettage for the evacuation of complete hydatidiform moles. Taiwanese Journal of Obstetrics and Gynecology, 58(5), 650-655.

Usui, H., Qu, J., Sato, A., Pan, Z., Mitsuhashi, A., Matsui, H., & Shozu, M. (2018). Gestational trophoblastic neoplasia from genetically confirmed hydatidiform moles: prospective observational cohort study. International Journal of Gynecologic Cancer, 28(9).

Usui, H., Sato, A., Ota, M., Ikeda, J. I., & Shozu, M. (2020). Androgenetic complete hydatidiform moles with p57KIP2-positive immunostaining. American Journal of Clinical Pathology, 154(6), 776-783.

Wang, J., Chen, S. W., Qin, X. Y., Zheng, X. Z., Wang, P., & Cai, X. Y. (2020). Clinical application of short tandem repeat polymorphism analysis in the differential diagnosis of early hydatidiform mole and hydropic abortion. Clinical and Experimental Obstetrics & Gynecology, 47(4), 490-495.

Winata, I. G. S., Kusuardiyanto, P., Aryana, M. B. D., & Mulyana, R. (2021). Cervical Hydatidiform Moles Pregnancy: Diagnosis and Treatment. Open Access Macedonian Journal of Medical Sciences, 9(C), 291-296.

Xing, D., Adams, E., Huang, J., & Ronnett, B. M. (2021). Refined diagnosis of hydatidiform moles with p57 immunohistochemistry and molecular genotyping: updated analysis of a prospective series of 2217 cases. Modern Pathology, 34(5), 961-982.

Xing, D., Miller, K., Beierl, K., & Ronnett, B. M. (2022). Loss of p57 Expression in Conceptions Other Than Complete Hydatidiform Mole: A Case Series With Emphasis on the Etiology, Genetics, and Clinical Significance. The American Journal of Surgical Pathology, 46(1), 18-32.

Yamamoto, E., Kanal, K., Soeung, S. C., Fujita, N., Krang, S., Long‐Hay, P., ... & Hamajima, N. (2021). The current situation of health services for hydatidiform mole in Cambodia. Journal of Obstetrics and Gynaecology Research, 47(10), 3652-3660.

Downloads

Published

2022-01-19

How to Cite

Mutalib, D. T. Y. (2022). Prevalence and Factors Associated with Hydatidiform Mole among Patients with Missed Abortion. International Journal of Humanities and Education Development (IJHED), 4(1), 61-66. https://doi.org/10.22161/